Study reveals synthesis of camphene-based spiroisoxazolines exhibiting antiviral activity against H1N1, suggesting potential therapeutic applications.
Abstract 1,3‐Dipolar cycloaddition reactions of nitrile oxides to camphene were studied. Slow diffusion of DIPEA vapor into a solution containing N‐hydroxyimidoyl halide as a precursor of 1,3‐dipole was used to effectively generate unstable nitrile oxides. For the first time, the regio‐ and stereoselectivity of the nitrile oxides cycloaddition to camphene was established: 1,3‐dipoles add from the exo side of C═C double bond with the formation of 5‐spiro oxazolidines. Synthesized spiroisoxazolidines were tested for antiviral activity against the influenza A virus of H1N1 subtype; compounds with a reasonable inhibitory effect and selectivity were revealed.
No takes yet. Share an insight, caveat, or question.
Shybanov et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: