Case report highlights Sars-Cov-2 persistence in granulomas and lung tissue of COVID-19 patient, suggesting fibrosis.
A case report of pulmonary sarcoidosis with fibrosis after COVID-19 is presented. Morphologic and immunohistochemical analysis of lung biopsies for Sars-Cov2 nucleocapsid and adhesion proteins was performed. Virus proteins were detected in alveolar macrophages, second-order pneumocytes and bronchiolar epithelium, also in granuloma-associated macrophages, multinucleated Pirogov-Langhans cells, indicating Sars-Cov2 persistence. Meanwhile, release of pro-inflammatory cytokines by granuloma cells and interstitial macrophages resulted in tissue damage and pulmonary fibrosis.
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Коган et al. (2025) studied this question.
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