Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity

Mintaek Oh; Woonza Rhee; Tianyi Zheng; Myongsoo Lee; Young Yong Kim; Yongju Kim

doi:10.1039/d5nr02944a

January 1, 2025Nanoscale

Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity

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Key Points

Isomer-driven supramolecular behavior affects cellular uptake and cytotoxicity of 4-hydroxytamoxifen.
Key evidence reveals that specific isomers modulate nanostructure-dependent cytotoxic effects significantly.
Analysis conducted on the interaction between geometric isomers and their biological functions, focusing on nanostructures.
Findings suggest that understanding isomerism can lead to innovative approaches in drug design and application.

Implication

Observational analysis shows isomer-driven changes in cytotoxicity via nanostructure effects, indicating new therapeutic insights.

Abstract

Geometric isomerism in small-molecule drugs has traditionally been studied in the context of receptor binding or metabolic stability. However, its influence on supramolecular behavior and downstream biological function remains underexplored....

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Cite This Study

Oh et al. (2025) studied this question.

synapsesocial.com/papers/68c187209b7b07f3a0610fa4 https://doi.org/10.1039/d5nr02944a

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Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity

Key Points

Implication

Abstract

Discussion

Cite This Study

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