Bilateral Secondary Glaucoma Associated with Congenital Herpes Simplex Virus Keratitis: A Case Report and Review of the Literature

To highlight a relatively underappreciated yet significant complication of neonatal ocular herpes simplex virus (HSV) infection. Observational case report of a 4-week-old patient with congenital ocular HSV infection over the course of 6-year follow-up. We describe a case of a neonate who developed bilateral HSV keratitis who subsequently developed bilateral glaucoma 9 months following primary infection. This patient ultimately required multiple goniotomies and glaucoma drainage device placement to achieve IOP control. We hypothesize that the combination of initial HSV infection and associated inflammation damaged the trabecular meshwork and led to peripheral anterior synechiae, ultimately reducing outflow in this patient's developing eyes. This case is an example of a potentially underappreciated manifestation of congenital ocular HSV and its complications.