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Supplementary figures assess the role of commensal bacteria in B-cell lymphomagenesis in mice with innate immunodeficiency.
Supplementary Figure S1. Analysis of ERV reactivation in aging M-Traf3-/- mice with BCL and WT mice. Supplementary Figure S2. Assessment of gut barrier integrity and commensal bacterial transmigration in aging WT and MTraf3-/- mice. Supplementary Figure S3. Increased frequency of IgG-coated fecal commensal bacteria of aging M-Traf3-/- mice. Supplementary Figure S4. Altered phenotype of MLN B cells from aging M-Traf3-/- mice. Supplementary Figure S5. Up-regulated expression of CD95 and CD86 on MLN B cells of aging M-Traf3-/- mice. Supplementary Figure S6. Aging M-Traf3-/- mice with spontaneous BCL exhibited high serum titers of antibodies against commensal bacterial proteins. Supplementary Figure S7. Analysis of commensal bacteria-reactivity and autoreactivity for BCL derived from aging M-Traf3-/- mice. Supplementary Figure S8. UpSet plots illustrating overlapping and distinct pathobiont ASVs across different sample types within individual aging M-Traf3-/- mice. Supplementary Figure S9. UpSet plots illustrating shared and unique pathobiont ASVs within the same sample type across different individual aging M-Traf3-/- mice.
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Jung et al. (2025) studied this question.
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