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January 1, 2025RSC AdvancesOpen Access

Bioassay-guided isolation of terpenoids from the soft coral Sclerophytum humesi and assessment of their antidiabetic and cytotoxic activities

Luu Vu Phuong Quoc-Dung Tran Huynh Ngoc-Thac Pham Huong-Giang Le Lo-Yun Chen Cường Quốc Nguyễn Huong Lien Ton-Nu Mei‐Hsien Lee Yu‐Chia Chang Jui-Hsin Su Bo‐Rong Peng Kuei-Hung Lai

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Key Points

The study identifies terpenoids with potential antidiabetic effects from Sclerophytum humesi, paving the way for new treatments.
This first report on bioactive compounds from soft coral Sclerophytum humesi highlights the discovery of secondary metabolites.
The bioassay-guided isolation method demonstrated the efficacy of terpenoids in exhibiting cytotoxic activities against cancer cells.
Identifying these compounds could lead to innovative approaches in developing therapeutic agents for diabetes and cancer.

Implication

Bioassay method identified terpenoids with antidiabetic and cytotoxic effects from Sclerophytum humesi, suggesting potential therapeutic uses.

Abstract

This study represents the first report on the secondary metabolites from the soft coral Sclerophytum humesi .

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Cite This Study

Phuong et al. (2025) studied this question.

synapsesocial.com/papers/68c189e79b7b07f3a0613f97 https://doi.org/10.1039/d5ra04971g

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1New Terpenoids from the Soft Coral <i>Sarcophyton trocheliophorum</i> and Their Anti‐inflammatory Activities2025 · 1 citations
2Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral <i>Sclerophytum humesi</i>Original Research · 2026 · 3 citations
3Xeniaphyllane-Type Diterpenoids from the Soft Coral <i>Sclerophytum humesi</i> : Resolving Absolute Configurations and Anti-Alzheimer’s PotentialOriginal Research · 2026 · 1 citations
4Analysis of Cembrane-Type Diterpenoids from Cultured Soft Coral Sclerophytum flexibile for Inhibition of TGF-β-Induced IL-6 Secretion in Inflammation-Associated Cancer2025
5Terpenoids of Sinularia soft corals: chemistry and bioactivityReview · 2012 · 118 citations

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Evaluation of potential cytotoxicity of the extracts from soft corals collected from the Philippine Sea of Mindanao: Sarcophyton glaucum, Lobophytum pauciflorum, Sinularia flexibilis and Lobophytum crassum2019
GC-MS Profiling of Secondary Metabolites in Hexane and Ethyl Acetate Crude Extracts of Red Sea Soft Coral <i>Xenia macrospiculata</i>2024
Cathepsin B-Oriented Screening, Isolation, and Antitumor Validation of Bioactive Metabolites from Sargassum polycystum2026

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