Adulthood presentation of Hirschsprung’s disease

In 90% of cases, Hirschsprung’s disease (HD) in adults occurs before the age of five. The primary characteristic is the absence of ganglion cells in the colorectal segment, resulting in upstream colonic dilatation and functional obstruction. Any history of chronic constipation should raise suspicions of HD. A combination of radiological, histological, clinical, and manometric results forms the basis of the diagnosis. The mainstay of treatment is surgery, which involves cutting off the aganglionic segment and then re-establishing continuity between the two healthy segments.