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September 10, 2025Science Advances0 citationsOpen Access

Ndc80 Complex Facilitates Kinetochore-Microtubule Sliding Mechanism

Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch

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Authors

VDVladimir DemidovIGIvan V. GoncharSTSuvranta K. Tripathy

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Overview

Analysis reveals Ndc80's dual behavior influences microtubule binding in kinetochores, indicating friction regulation.

Key Points

  • Ndc80 complexes enable bidirectional sliding along microtubules, a crucial aspect of chromosome motion.
  • Under tension, Ndc80 exhibits a catch bond that increases adhesion, while opposing force switches to slip-bond behavior.
  • Ultrafast force-clamp spectroscopy was used to observe single Ndc80 complex interactions with microtubules, demonstrating sliding dynamics.
  • Understanding Ndc80's friction regulation is vital for elucidating kinetochore-microtubule interactions and their mechanics.

Cite This Study

Demidov et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a06154d8https://doi.org/10.1126/sciadv.adx0005
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: a push-pull mechanism1993 · 416 citations
  2. 2Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface2020 · 54 citations
  3. 3Orientation and structure of the Ndc80 complex on the microtubule lattice2008 · 100 citations