Phospha-Peterson reactions with esters and thioesters: Isolation of phosphaalkenes bearing C-heteroatom substituents †

Aaron A. Mitchell; Paul Heine; Joseph Chang; Adam De Paolis; Brian O. Patrick; Derek P. Gates

doi:10.1039/d5dt01781e

January 1, 2025Dalton Transactions

Phospha-Peterson reactions with esters and thioesters: Isolation of phosphaalkenes bearing C-heteroatom substituents †

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Key Points

Phosphaalkenes were synthesized using various ester and thioester reagents, enhancing C-heteroatom substitution.
Key reactions involved treatement with KOH catalysts, showcasing efficient conversion of silylphosphines.
Multiple phospha-Peterson pathways reveal the versatility in generating diverse phosphaalkenes.
The methods explored could pave the way for developing new compounds in organophosphorus chemistry.

Implication

Experimental analysis explores phospha-Peterson reactions to generate phosphaalkenes with heteroatom groups, indicating novel synthesis routes.

Abstract

Several phospha-Peterson routes to phosphaalkenes from silylphosphines and various ester or thioester reagents are investigated. Treatment of MesP(SiMe 3 ) 2 with PhCO(OPh) in the presence of KOH (10 mol%)...

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Mitchell et al. (2025) studied this question.

synapsesocial.com/papers/68c18f409b7b07f3a0615f0c https://doi.org/10.1039/d5dt01781e

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Phospha-Peterson reactions with esters and thioesters: Isolation of phosphaalkenes bearing C-heteroatom substituents †

Key Points

Implication

Abstract

Discussion

Cite This Study

Phospha-Peterson reactions with esters and thioesters: Isolation of phosphaalkenes bearing C-heteroatom substituents †

Key Points

Implication

Abstract

Discussion

Cite This Study

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