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September 10, 2025Advancements in Life SciencesOpen Access

α-globin gene 20.5kb deletion and triplication mutations among Palestinian patients with microcytic hypochromic anemia

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Authors

LSLamia'a Sobhi SaqerFHFathi HassanFSFadel A. Sharif

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Overview

Observational analysis found high rates of α-thalassemia mutations in Palestinians with anemia, suggesting genetic predisposition.

Key Points

  • About 33% of participants had α-thalassemia, highlighting prevalence in this population.
  • The frequencies of mutations were 13.25% for -α20.5 and 5.5% for αααanti3.7, indicating genetic variability.
  • Molecular detection used Multiplex-PCR, a method effective for identifying genetic mutations.
  • Further testing is needed to detect more α-thalassemia mutations, which could provide insight into the disease.

Cite This Study

Saqer et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a06169f6https://doi.org/10.62940/als.v12i2.2161
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Severe Transfusion-Dependent Thalassemia in Compound Heterozygote Palestinian Siblings with Two α-Globin Gene Defects, Hb Taybe D <i>HBA1</i> : C.119_121delCCA Mutation and <i>HBA2</i> : C.*94A &gt; G Mutation2024
  2. 2Detection of Common Deletion Mutations in HBA gene and Genotype-Phenotype Correlation2024
  3. 3Molecular Spectrum of α-Thalassemia Mutations in Antalya, Türkiye and Their Relationship with Hematological Parameters2026
  4. 4Alpha globin gene alterations modifying the phenotype of homozygous beta thalassaemia2024 · 7 citations
  5. 5Spectrum of α- and β-thalassemia variants in individuals with persistent microcytic hypochromia in Eastern Iran: implications for population genetic screening2026