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January 1, 2025Biomaterials Science

Glycyrrhetinic acid functionalized polyamidoamine dendrimers for targeted gene delivery in liver cancer

Meijun Wang Yujing Sang Xinyu Qin Ji Li Hao Wang Rui Yu Tiantian Jin Yiqing Lu Yue Cong Bingyang Shi

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Key Points

The GA-PPI/pDNA polyplexes enhance targeted delivery of genetic material to liver cancer cells.
These polyplexes could represent a promising advancement in gene therapy approaches for liver cancer.
The methodology involves functionalizing dendrimers with glycyrrhetinic acid to improve delivery efficiency.
This research highlights potential new strategies for liver cancer treatment, paving the way for future therapies.

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Implication

Polyamidoamine dendrimers facilitate pDNA delivery in liver cancer, suggesting effective cancer treatment options.

Abstract

GA-PPI/pDNA polyplexes hold significant promise for the treatment of liver cancer.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a0616bfa https://doi.org/10.1039/d5bm01037c

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Receptor Targeting Using Copolymer-Modified Gold Nanoparticles for pCMV-Luc Gene Delivery to Liver Cancer Cells In Vitro2024 · 12 citations
2Preparation and anti-tumor effect in hepatocellular carcinoma treatment of AS1411 aptamer-targeted polyphyllin II-loaded PLGA nanoparticles2024 · 8 citations
3Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene DeliveryOriginal Research · 2017 · 35 citations
4Targeted pharmacokinetics of polymeric micelles modified with glycyrrhetinic acid and hydrazone bond in H22 tumor-bearing micepreclinical · 2019 · 16 citations
5Reengineering glycyrrhetinic acid into a therapeutic oligomer for targeted tumor therapy with cardioprotectionpreclinical · 2025 · 5 citations

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