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September 10, 2025Journal of the American Chemical Society

Regioselective Hydroamidation of α,β-Unsaturated Esters Enabled by Lewis Acid/Iron Relay Catalysis

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Authors

HCHoonchul ChoiDKDongwook KimSCSukbok Chang

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Overview

This dual boron/iron catalytic system achieves α-amidated esters in hydroamidation, suggesting a breakthrough for regioselective reactions.

Key Points

  • The process leads to exclusive formation of α-amidated esters, indicating a significant advancement in regioselectivity.
  • Utilizing a dual boron/iron system, the reaction operates under mild conditions with only 1 mol % of each catalyst.
  • The dual role of chloride anions enhances catalytic reactivity, showing potential for complex substrate applications.
  • The methodology accommodates a wide variety of unsaturated esters, highlighting its operational simplicity and versatility.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/68c192579b7b07f3a0616ee4https://doi.org/10.1021/jacs.5c08838
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