Ultrasound Activated Copper-Based Sonosensizer for Dual-Amplified ROS-Mediated Tumor Therapy and Cuproptosis Induction

Penghui Wang; Runming Zhong; Yingzhe Wu; Lingli Jin; Yanan Zhang; Kai Zhang; Fan Zhao

doi:10.1039/d5tb01691f

January 1, 2025Journal of Materials Chemistry B

Ultrasound Activated Copper-Based Sonosensizer for Dual-Amplified ROS-Mediated Tumor Therapy and Cuproptosis Induction

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Key Points

Enhanced ROS production using ultrasound activation significantly improves tumor therapy outcomes.
Copper-based sonosensizers proved highly effective in mediating tumor cell death through cuproptosis.
Application of sonodynamic therapy represents a promising alternative for noninvasive cancer treatment.
This approach demonstrates the potential of using ultrasound to amplify therapeutic efficacy in solid tumors.

Implication

Novel ultrasound-activated therapy improves ROS generation in tumors, suggesting a new approach for cancer treatment.

Abstract

Sonodynamic therapy (SDT) is a promising noninvasive cancer treatment with deep tissue penetration, but its therapeutic efficacy is limited by insufficient reactive oxygen species (ROS) production. Herein, we developed copper-based...

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c193de9b7b07f3a0617904 https://doi.org/10.1039/d5tb01691f

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Ultrasound Activated Copper-Based Sonosensizer for Dual-Amplified ROS-Mediated Tumor Therapy and Cuproptosis Induction

Key Points

Implication

Abstract

Discussion

Cite This Study

Ultrasound Activated Copper-Based Sonosensizer for Dual-Amplified ROS-Mediated Tumor Therapy and Cuproptosis Induction

Key Points

Implication

Abstract

Discussion

Cite This Study

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