Case report reveals conservative management of ALK-negative inflammatory myofibroblastic tumor, suggesting effective medical therapy. Patient experienced regression after stenting and medication.
A 55-year-old female presented with left flank pain and ureteral obstruction. Imaging revealed a retroperitoneal mass suspicious for malignancy. Histopathology confirmed an inflammatory myofibroblastic tumor (IMT; anaplastic lymphoma kinase [ALK]-negative, mouse double minute 2 homolog-positive). Due to vascular encasement prohibiting safe resection, cystoscopic ureteral stenting was performed followed by 12 months of prednisone and celecoxib therapy. Serial imaging showed progressive regression, with near-resolution at 36 months. This demonstrates successful medical management of unresectable ALK-negative retroperitoneal IMT.
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Lin et al. (2025) studied this question.
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