Observational analysis finds higher prevalence of cytomegalovirus and Epstein-Barr virus in acute-on-chronic liver failure patients, indicating possible viral contribution to the condition.
Background & Aims: Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome characterized by acute decompensation and multi-organ failure in patients with pre-existing chronic liver disease. Patients who develop ACLF within 90 days are referred to as pre-ACLF. Known precipitants include bacterial infections and viral hepatitis. However, in 40-60% of patients the precipitant remains unknown. Cytomegalovirus (CMV) and Epstein Barr virus (EBV) are highly prevalent viruses, but their impact on ACLF is unclear.
No takes yet. Share an insight, caveat, or question.
Sonnenberg et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: