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September 10, 2025Zeitschrift für Gastroenterologie

Long-term efficacy and safety of open-label seladelpar treatment in patients with primary biliary cholangitis: pooled interim results for up to 3 years from the ASSURE study

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Authors

ELE.J. LawitzPTP.J. TrivediKKKris V. Kowdley

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Overview

Long-term results show seladelpar treatment improves outcomes in primary biliary cholangitis patients, indicating its potential as a therapeutic option.

Key Points

  • Seladelpar treatment demonstrates sustained efficacy in primary biliary cholangitis patients over 3 years.
  • The interim results highlight safety profiles consistent with prior trials, supporting ongoing use.
  • Phase 3 ASSURE trial involved patients with inadequate response to ursodeoxycholic acid.
  • Long-term data from the ASSURE study could influence treatment guidelines for primary biliary cholangitis.

Cite This Study

Lawitz et al. (2025) studied this question.

synapsesocial.com/papers/68c193fb9b7b07f3a06184d0https://doi.org/10.1055/s-0045-1810647
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