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Research uncovers the role of adipose tissue in cachexia among pancreatic cancer patients, indicating potential interventions.
Introduction: Up to 85% of pancreatic ductal adenocarcinoma (PDAC) patients are afflicted with cachexia – a metabolic syndrome characterized by loss of skeletal muscle mass and adipose tissue (AT) wasting. Cachexia worsens the already reduced quality of life of PDAC patients, their ability to tolerate therapeutic interventions, and, ultimately, their survival. Drawing insights from obesity research, where local changes in the adipose tissue play a crucial role in the pathophysiology, we explore adipose tissue in the context of PDAC cachexia at single-cell resolution.
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Hambitzer et al. (2025) studied this question.
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