Analysis reveals spatial dynamics of hepatic stellate cells and macrophages in cirrhosis, suggesting roles in HCC onset.
Introduction and aims: Hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, often arises in the context of cirrhosis. This study investigates the spatial dynamics and functional contributions of hepatic stellate cells (HSCs/CAFs), macrophages (Mph/TAMs), and hepatocytes across distinct regions—distant cirrhosis (C), cirrhosis at the tumor margin (CT), and intratumoral tissue (T)—to elucidate mechanisms driving hepatocarcinogenesis.
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Hammad et al. (2025) studied this question.
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