Integrated protein engineering and bioreactor design enhance chiral aryl alcohol yields, suggesting a pathway to overcome acetone limitations.
The asymmetric biosynthesis of chiral aryl alcohols at high substrate concentrations is hindered by acetone accumulation, a byproduct of isopropanol-mediated cofactor regeneration. Here, a structure-guided mutant carbonyl reductase LXCAR-S154Y/I145A/R191Q (LXCAR-Q3)...
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Qian et al. (2025) studied this question.
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