Investigation reveals vital forensic implications of angioedema-anaphylaxis deaths in COVID-19, highlighting the role of mast cell activation and bradykinin pathways.
Gray et al's investigation into angioedema–anaphylaxis deaths amidst the COVID-19 pandemic raises important forensic implications, particularly concerning differential diagnostics in postmortem settings ( 1 ). However, a critical avenue requiring deeper contextualization is the immunopathological intersection between SARS-CoV-2-induced mast cell activation and bradykinin-mediated pathways ( 2 ).
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Aban et al. (2025) studied this question.
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