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September 10, 2025Translational Vision Science & TechnologyOpen Access

P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal

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BAY-776 significantly reduced ocular pain responses after lacrimal gland removal, indicating effective pain relief.
Rats treated with BAY-776 showed notable reductions in inflammatory cell density and corneal nerve plexus changes compared to controls.
Assessment included various tests, confirming the pain reduction effects of BAY-776 across multiple measurement methods.
These findings suggest BAY-776 could serve as a promising treatment for managing chronic ocular pain.

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Implication

Experiment shows P2X4 receptor antagonist effectively reduces ocular pain in male rats, highlighting its potential therapeutic role in chronic pain management.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c198ab9b7b07f3a0619d23 https://doi.org/10.1167/tvst.14.9.11

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Implication

Experiment shows P2X4 receptor antagonist effectively reduces ocular pain in male rats, highlighting its potential therapeutic role in chronic pain management.

P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal

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Implication

Cite This Study

P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal

Key Points

Discussion

Implication

Cite This Study

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