This report reveals the synthesis of 8-phenyl tetrahydroisoquinoline, finding significant antidepressant activity in select analogs, indicating potential for treating depression.
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8‐phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnoflorine by a structural simplification strategy. The present report details the synthesis and antidepressant activity studies of 8‐phenyl‐THIQ analogs. Among them, compounds 1e and 1j exhibited significant antidepressant activity in addition to high synthetic accessibility and adequate predictive ADME/T properties.
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Wei et al. (2025) studied this question.
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