Lantana camara L. leaf extract-loaded chitosan nanoparticles induce apoptosis and suppress PI3K/AKT and NF-κB signalling in triple-negative breast (MDA-MB-231) and colorectal cancer (HCT116) cells
Observational analysis shows apoptosis induction in triple-negative breast cancer and colorectal cancer cells, suggesting LC-ChNPs may serve as novel phytomedicine.
Key Points
Significant cytotoxicity was observed in both triple-negative breast cancer and colorectal cancer cells.
Key oncogenic proteins PI3K, AKT, and NF-κB were strongly downregulated after treatment with LC-ChNPs.
Treatment increased ROS generation and enhanced caspase-3 activity, indicating cellular stress and apoptosis induction.
The study highlights the potential of LC-ChNPs as a targeted therapy in aggressive cancer types.