The launch of ChatGPT in November 2022 accelerated discussions and research into whether base large language models (LLMs) could increase the efficiency of qualitative analysis phases or even replace qualitative researchers. Reflexive thematic analysis (RTA) is a commonly used method for qualitative text analysis that emphasizes the researcher’s subjectivity and reflexivity to enable a situated, in-depth understanding of knowledge generation. Researchers appear optimistic about the potential of LLMs in qualitative research; however, questions remain about whether base models can meaningfully contribute to the interpretation and abstraction of a dataset. The primary objective of this study was to explore how LLMs may support an RTA of an interview text from health science research. Secondary objectives included identifying recommended prompt strategies for similar studies, highlighting potential weaknesses or challenges, and fostering engagement among qualitative researchers regarding these threats and possibilities. We provided the interview file to an offline LLM and conducted a series of tests aligned with the phases of RTA. Insights from each test guided refinements to the next and contributed to the development of a recommended prompt strategy. At this stage, base LLMs provide limited support and do not increase the efficiency of RTA. At best, LLMs may identify gaps in the researchers’ perspectives. Realizing the potential of LLMs to inspire broader discussion and deeper reflections requires a well-defined strategy and the avoidance of misleading prompts, self-referential responses, misguiding translations, and errors. Conclusively, high-quality RTA requires a human, comprehensive familiarization phase, and methodological competence to preserve epistemological integrity.
Vikan et al. (2025) studied this question.