A Comparative Study Between Mouriquand's Grading System and Robinson's Grading System for Reporting Breast Cancer Cytopathology and Their Histopathological Correlation

Background: Breast cancer remains the most common malignancy among women globally, with an increasing incidence in India, where late-stage diagnoses are prevalent.Various cytological grading systems, includingMouriquand's andRobinson's, help assesstumourseverity,with correlationsto histological grading systems like Nottingham's Bloom Richardson. The goal is to evaluate the reliability of these cytological grading methods in assessing tumor behavior and guiding treatment decisions, thereby improving breast cancer care and prognosis. Methodology: This prospective study was conducted in the Department of Pathology at GMC,Amritsar.50 Female patients with complaints of lump in the breast and diagnosed with breast cancer on FNAC were included in study. Then the breast cancer cases were graded according to Mouriquand's grading system and by Robinson's grading, and the results thus obtained were correlated with Nottingham's Bloom Richardson histopathology. Results: Our results showed that Mouriquand'ssystemandRobinson'ssystemyielded slightly different distributions of cases on the grading system.Both systemsshowed concordance and correlation but still some degree of discordance, particularly in grade II tumours, because Mouriquand's grading system, often overestimated the tumour grade.Robinson's cytological grading systemalignssignificantlywithNottingham'sBloomRichardson grading system(Pearson r=0.633) and shows the highest concordance (κ = 0.555, 74%) in comparision the moriquand's cytological grading system (Pearson r = 0.483) and concordance (κ=0.083, 58.3%) at a non-significant p-value. Robinson's grading system showed the highest diagnostic accuracy in predicting Cytological grade as compared to Mouriquand'ssystem.It also had highersensitivity and specificity compared to Mouriquand's, when correlated with Nottingham'sBloom Richardson grading making Robinson's grading system a more reliable and reproducible method for grading of breast carcinoma on FNAC. Conclusion: Robinsons grading system revealed strong correlations, with Nottingham's's histopathological demonstrating superior sensitivity and specificity.Diagnostic accuracycomparisonsindicate thatRobinson'ssystemoutperformsMouriquand's gradingsystem.