Observational analysis shows DDIT4 modulates macrophage polarization and inflammation in diabetic kidney disease, highlighting a potential treatment target.
Objectives In this study, we explored the mechanism by which DDIT4 influences the polarization phenotypic transformation of macrophages and inflammation through the regulation of mTOR signaling pathway, providing a new mechanism and target for the treatment of diabetic nephropathy.
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Shi et al. (2025) studied this question.
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