What type of study is this?

This is a Simulated trials study.

September 10, 2025JBJS Open AccessOpen Access

The Fallacy of Patient-Reported Outcome Measures

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Authors

NONathan N. O’HaraUniversity of Maryland, Baltimore DBDane J. BrodkeUniversity of Maryland, Baltimore ALAshley E. LevackLoyola University Medical Center

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Implication

Simulation study compares detection of meaningful differences in treatments for tibial shaft fractures, suggesting limitations of patient-reported outcomes.

Key Points

A significant 80.9% of trials found differences using nonunion surgery as the primary outcome, unlike only 4.2% for PROMIS scores.
Comparisons of treatments in 10,000 simulated trials highlighted the sensitivity of nonunion outcomes over continuous PROMIS scores.
Assuming a 400-patient sample, most trials failed to detect significant differences when relying on patient-reported outcomes.
Orthopaedic researchers must recognize the limitations of patient-reported measures when evaluating treatment effects.

Cite This Study

O’Hara et al. (2025) studied this question.

synapsesocial.com/papers/68c199e89b7b07f3a061b731 https://doi.org/10.2106/jbjs.oa.25.00172

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Implication

Simulation study compares detection of meaningful differences in treatments for tibial shaft fractures, suggesting limitations of patient-reported outcomes.

The Fallacy of Patient-Reported Outcome Measures

Discussion

Member takes

Implication

Key Points

Cite This Study

The Fallacy of Patient-Reported Outcome Measures

Discussion

Member takes

Implication

Key Points

Cite This Study

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