Drug eruption induced by the intake of comprehensive cold medicine: A case report

Rationale: Taisho Comprehensive Cold Medicine is a Japanese drug known for its effective action against the common cold. It was widely used by the Chinese individuals. Meanwhile, the cold medicine is associated with several adverse effects. Although some drug eruptions induced by paracetamol have been reported, those induced by comprehensive cold medicine have not been studied. Patient concerns: A 7-year-old child presenting with an upper respiratory tract infection developed drug eruptions with symptoms of significant pruritus and skin rash, after 2 days of therapy with Taisho Comprehensive Cold Medicine. Diagnoses: The clinical symptoms and the laboratory examination confirmed drug eruption, accompanied by mild renal impairment. And Taisho Comprehensive Cold Medicine-induced drug eruption and renal impairment was considered. The Naranjo Adverse Drug Reaction Probability Scale score was 7 points, which is categorized as “probable.” Interventions: The doctor ceased the treatment of cold medicine and monitored the patient daily. Outcomes: The drug eruption disappeared 5 days after drug withdrawal. Lessons: Although Taisho Comprehensive Cold Medicine has been approved for its use in children over the age of 1 year, it is necessary to clarify whether children under the age of 18 have a history of allergies when prescribing or administering this medicine. And medication should be taken under the supervision of a doctor. Once adverse reactions occur, stop taking the medicine immediately. This is the 1st known case of Taisho Comprehensive Cold Medicine-induced drug eruption. The awareness of rare adverse reaction helps ensure the clinical safety of Taisho Comprehensive Cold Medicine treatment in Chinese children.