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September 10, 2025Journal of Psychiatry and Neuroscience

Continuing the search for the engram: examining the mechanism of fear memories

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Authors

SJSheena A. Josselyn

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Overview

Observational analysis reveals the role of CREB in fear memories, implicating specific neurons in the lateral amygdala.

Key Points

  • Overexpressing CREB in lateral amygdala neurons enhances fear memory formation, suggesting molecular memory mechanisms.
  • Selective ablation of CREB-overexpressing neurons disrupts fear memories, indicating critical neuron involvement in memory networks.
  • Rodent models provide insights into the cellular basis of fear memories, highlighting potential targets for psychiatric disorder treatments.
  • These findings advance our understanding of the molecular underpinnings of fear memory and related psychiatric conditions.

Cite This Study

Sheena A. Josselyn (2010) studied this question.

synapsesocial.com/papers/68c199f49b7b07f3a061c09chttps://doi.org/10.1139/jpn.100015
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