Observational analysis demonstrates that Tacca chantrieri reduces cell viability and induces apoptosis in breast cancer cell lines, suggesting its potential as an alternative treatment.
Breast cancer is the most common cancer in females worldwide, and standard chemotherapy often causes significant side effects. Tacca chantrieri, a plant used in traditional medicine, contains bioactive compounds with anti-cancer properties. This study aimed to evaluate the anti-cancer activity of T. chantrieri rhizome extract (TCE) on breast cancer cell lines. The rhizomes of T. chantrieri were extracted with 95% ethanol and used to treat MDA-MB-231, MCF-7, and SK-BR-3 breast cancer cell lines. Cell viability was assessed using the MTT assay. Apoptosis was evaluated by annexin V and propidium iodide staining, while colony formation and cell migration were assessed using clonogenic and wound healing-scratch assays, respectively. The results showed that TCE significantly reduced cell viability, induced apoptosis, and inhibited colony formation and migration. In conclusion, TCE exhibits anti-cancer activity against breast cancer cells, highlighting its potential for further development as an alternative treatment for breast cancer. HIGHLIGHTS T. chantrieri rhizome extract (TCE) exhibited anti-cancer breast activity. TCE reduced the viability of MDA-MB-231, MCF-7, and SK-BR-3 cell lines. TCE induced apoptosis of MDA-MB-231, MCF-7, and SK-BR-3 cell lines. TCE inhibited colony formation and migration of MDA-MB-231, MCF-7, and SK-BR-3 cell lines.
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Thewaanukhor et al. (2025) studied this question.
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