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September 10, 202515 citationsOpen Access

Thianthrenium Salt-Mediated Approach for Alkene 1,3-Difunctionalization

Thianthrenium Salt‐Mediated Homologative 1,3‐Dielectrophilic Activation Strategy for Alkene Difunctionalization

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Authors

SPSubhasis PaulARAdam RichardsonLBLeslie T. Buck

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Overview

Novel thianthrenium salt strategy enables 1,3-difunctionalization of alkenes, suggesting broad synthetic applications.

Key Points

  • The method allows for the efficient formation of diverse 1,3-difunctionalized products, expanding alkene transformation applications.
  • Thianthrenium salt-mediated activation reveals previously challenging routes to create 1,3-diazides and diamines with high efficiency.
  • A new sulfonium atom-transfer reagent facilitates targeted activation and bond cleavage for effective synthesis of functional groups.
  • This strategy could pave the way for the development of more complex molecules, highlighting the potential of electrophilic synthons.

Cite This Study

Paul et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12754b1d3bfb60dbf8dhttps://doi.org/10.1002/anov.70005
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