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September 10, 2025Angewandte Chemie

Molecular Rotor‐Based NIR‐II TICTgens for Mitochondria‐Targeted Pyroptosis Induction and Multi‐Model Monitoring of Cancer Immunotherapy

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Authors

MLMin LiJGJing GaoYXYaxiong Xie

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Overview

This study demonstrates TICTgens inducing tumor-targeted pyroptosis and monitoring immune response in cancer therapy.

Key Points

  • HCM effectively triggers pyroptosis in tumor cells, enabling robust antitumor immunity through mitochondrial damage.
  • The study highlights the use of TICTgen HCM that generates reactive oxygen species, enhancing pyroptosis induction.
  • Delivered via nanoparticles, HCM allows in situ monitoring of tumor cell pyroptosis using NIR-II fluorescence imaging.
  • Combining PDPA@HCM NPs with immune checkpoint therapy resulted in significant colorectal tumor regression in a mouse model.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1a13a54b1d3bfb60dcac5https://doi.org/10.1002/ange.202508646
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