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September 10, 2025Frontiers in OncologyOpen Access

Polyamine metabolism related gene index prediction of prognosis and immunotherapy response in breast cancer

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Authors

RWRuoya WangSCShouliang CaiQGQing Gao

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Overview

Multi-omics analysis reveals biomarkers predicting prognosis and immunotherapy response in breast cancer.

Key Points

  • The polyamine metabolism gene index can successfully stratify breast cancer patients into high-risk and low-risk groups, indicating prognosis.
  • A prognostic model was constructed from six key polyamine metabolism-related genes, validated by ROC curve analysis in METABRIC and GSE86166 cohorts.
  • The study highlights significant differences in immune status and drug sensitivity between distinct prognostic groups based on polyamine metabolism.
  • Four independent prognostic factors were identified, enhancing the model's predictive performance and guiding clinical treatment strategies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd45fhttps://doi.org/10.3389/fonc.2025.1613458
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