A Ni/PyBCam protocol achieves regioselective ipso cross-coupling with diverse electrophiles, highlighting valuable building blocks.
A Ni/PyBCam-catalyzed protocol enables regioselective coupling at the ipso-carbon of homopropargyl bromides with aryl/vinyl electrophiles. This mild method utilizes bench-stable partners to access functionalized 1,4-biaryl and 1-aryl-4-vinyl internal alkynes─valuable synthetic building blocks. Mechanistic studies reveal initial homopropargyl-Ni formation, diverging from classical aryl-alkyl coupling pathways.
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Liu et al. (2025) studied this question.
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