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September 10, 2025Journal of NeurochemistryOpen Access

MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate

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Authors

KFKiavasch Mohammad Nejad FaridGoethe University FrankfurtRLRodrigo LerchundiHeinrich Heine University DüsseldorfCRChristine R. RoseHeinrich Heine University Düsseldorf

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Implication

Observational analysis shows oxidative phosphorylation increases in astrocytes with glutamate stimulation, indicating mGlu5 receptor's crucial role.

Key Points

  • Astrocytic oxidative metabolism increases in response to extracellular glutamate, enhancing energy production.
  • Mitochondrial translocation of PKCδ and activation of PDH are induced by glutamate, vital for carbohydrate utilization.
  • Blocking mGlu5 reduces ATP production in astrocytes, emphasizing its role in metabolic adaptation to neuronal activity.
  • Upregulation of astrocytic metabolism may impact perisynaptic energy dynamics without affecting the entire astrocyte.

Cite This Study

Farid et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd642https://doi.org/10.1111/jnc.70163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation2024 · 1 citations
  2. 2Protein Kinase C δ (PKCδ) Inhibits the Expression of Glutamine Synthetase in Glial Cells via the PKCδ Regulatory Domain and Its Tyrosine Phosphorylation1998 · 41 citations
  3. 3Activation of TRPV4 channels promotes the loss of cellular ATP in organotypic slices of the mouse neocortex exposed to chemical ischemia2023 · 21 citations
  4. 4How expensive is the astrocyte?2022 · 55 citations
  5. 5Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet2016 · 69 citations