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September 10, 2025The EMBO JournalOpen Access

ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains

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Observational analysis reveals ATXN3's crucial role in lysosome regeneration and lysophagy, indicating a targeted response to lysosomal damage.

Restoration of lysosomal function is facilitated by ATXN3, which targets specific ubiquitin chains on damaged lysosomes.
ATXN3's involvement in lysophagic flux confirms its importance in lysosomal repair mechanisms after damage.
Involvement of VCP/p97 indicates a collaborative mechanism underlined by K48-K63-branched ubiquitin chains.
The findings suggest potential therapeutic insights into lysosomal diseases by understanding the role of ATXN3 in membrane integrity.

Reinders et al. (2025) studied this question.

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Observational analysis reveals ATXN3's crucial role in lysosome regeneration and lysophagy, indicating a targeted response to lysosomal damage.