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July 31, 2025The Journal of Cell Biology

Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube

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Key Points

Epithelial tube formation requires spatial restriction of apical constriction during invagination.
Arc protein interacts with Crumbs, influencing actomyosin dynamics in the Drosophila salivary gland.
The study identifies a mechanism by which epithelial tissues shape into long, thin structures.
Understanding this process could inform how similar mechanisms work in other biological contexts.

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Implication

Research reveals Arc restricts actomyosin-driven apical constriction during salivary gland invagination, suggesting a role in tube formation.

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Cite This Study

Tony Harris (2025) studied this question.

synapsesocial.com/papers/68c1a40954b1d3bfb60de71f https://doi.org/10.1083/jcb.202507106

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Arc controls organ architecture through modulation of Crb and MyoII2024
2A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions2024
3Cell signaling facilitates apical constriction by basolaterally recruiting Arp2/3 via Rac and WAVE2024
4Dachsous is a key player in epithelial wound closure by modulating cell shape changes and cytoskeleton dynamics2024
5Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the <i>Drosophila</i> leg2024 · 4 citations