Efeitos da microbiota intestinal na modulação do eixo cérebro intestino em transtornos neurológicos

Introduction. The gut-brain axis connects the gastrointestinal environment to the Central Nervous System (CNS), being crucial for homeostasis. Changes in this connection are associated with neuropsychiatric disorders, such as depression and anxiety, often linked to gastrointestinal comorbidities. Objective. Explore the role of the gut microbiota in regulating the brain-gut axis and its contributions to the understanding and treatment of neurological disorders. Method. The research used an integrative literature review with data collected from databases such as PubMed and ScienceDirect. Articles published between 2014 and 2025 were selected, using descriptors such as "Gut microbiota", "Brain-gut axis" and "Neurological disorders”. After screening, 17 studies were included in the analysis. Results. The studies reviewed indicate that the intestinal microbiota plays a crucial role in regulating the brain-gut axis, influencing neurological disorders such as depression, Alzheimer's and Parkinson's. Changes in the microbiota affect neurotransmitters and inflammation, being. that interventions such as probiotics and specific diets show promise. Advanced technologies have expanded the understanding of these interactions, opening the way for new therapeutic approaches. Conclusion This article highlights the relationship between the intestinal microbiota and the brain-gut axis. healthy lives and interventions such as the use of probiotics contribute to the restoration of microbial balance and the reduction of neurodegenerative processes.