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September 10, 2025Small

Dynamic Antibacterial‐to‐Regenerative Switching via NIR/Visible Light Activation: Copper Single‐Atom Nanozyme with CO‐Mediated Scarless Healing for Chronic Diabetic Wounds

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Authors

MYMei YaoWuhan National Laboratory for OptoelectronicsXLXian LiBinzhou Medical UniversityWDWen DongYunnan Normal University

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Implication

Engineering a copper single-atom nanozyme enhances antibacterial and regenerative functions in diabetic wounds, implying a novel gas therapy approach.

Key Points

  • This treatment demonstrates near-scarless healing in diabetic wounds by effectively disrupting biofilms and improving vascularization.
  • The engineered copper single-atom nanozyme activated by light achieves potent antibacterial and anti-inflammatory effects against multidrug-resistant infections.
  • Photocatalytic gas therapy facilitates the transition from antibacterial to regenerative phases, enhancing the wound microenvironment through spatial control.
  • Integration of nanozyme catalysis with CO therapy highlights a promising approach for chronic wound management, requiring further testing in diverse models.

Cite This Study

Yao et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5f254b1d3bfb60dfaa9https://doi.org/10.1002/smll.202506681
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