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September 10, 2025Analytical Chemistry

Self-Sustaining miRNA Amplification Diagnostics via Catalytic Hairpin Assembly and Split Activator-Initiated CRISPR/Cas12a Hybrid Feedback Circuit with Target Regeneration and Recycling

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Authors

ZSZhuqi SuiBCBaoqiang ChenJZJia Zhao

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Overview

This platform demonstrates ultrasensitive miRNA detection in breast cancer, suggesting a novel hybrid diagnostic approach.

Key Points

  • The platform achieves attomolar sensitivity for detecting miRNA-155, a crucial biomarker for breast cancer.
  • It effectively addresses background leakage and fluorescence issues through an innovative feedback mechanism.
  • The dual-recognition approach ensures target specific detection, enhancing accuracy in differentiating breast cancer patients from healthy controls.
  • The design enables continuous amplification of signals, offering a scalable solution for low-abundance miRNA detection in clinical applications.

Cite This Study

Sui et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5ff54b1d3bfb60e00abhttps://doi.org/10.1021/acs.analchem.5c02845
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