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September 10, 2025Frontiers in NeurologyOpen Access

Exosomal circ₀093708 as a potential ferroptosis biomarker in cerebral ischemia–reperfusion injury

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Authors

SMShuyin MaXZXu Dong ZhangJFJiaxin Fan

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Overview

Analysis suggests exosomal circ_0093708 correlates with DUSP1 and PTGS2 in ferroptosis following cerebral ischemia, indicating potential as a diagnostic tool.

Key Points

  • Exosomal circ_0093708 is identified as a potential biomarker for ferroptosis in cerebral ischemia–reperfusion injury.
  • Results showed a high diagnostic accuracy with an area under the curve of 0.93, sensitivity of 90%, and specificity of 90%.
  • Key ferroptosis-associated genes, DUSP1 and PTGS2, were identified as potentially regulated by exosomal circRNAs.
  • Findings imply that inhibiting DUSP1 aggravates ferroptosis, highlighting its significance in therapeutic strategies.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5ff54b1d3bfb60e0115https://doi.org/10.3389/fneur.2025.1633393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circ_0008146 Exacerbates Ferroptosis via Regulating the miR-342-5p/ACSL4 Axis After Cerebral Ischemic/Reperfusion2024 · 7 citations
  2. 2CircDUSP22 Attenuates the Ferroptosis of Prostate Cancer Cells via miR-18a-5p/SLC7A11/GPX4 Signaling2024 · 3 citations
  3. 3Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting ABCB8 in Perioperative Neurocognitive Disorders After Prostate Surgery2026
  4. 4Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury Investigated via bioinformatics analysis and animal experiments2024
  5. 5DUSP1 Attenuates Renal Injury in Diabetic Nephropathy by Modulating Ferroptosis: Evidence From Animal Experiments2026