The Potential Antipyretic Activity of the Ethanolic Peel Extract of Artocarpus heterophyllus (Moraceae)

This study investigated the antipyretic potential of the ethanoic peel extract of A. heterophyllus (jackfruit) and compared its efficacy with the standard antipyretic drug, paracetamol. Fever, a common response to infections or inflammation, often requires antipyretics to alleviate symptoms. The peel of A. heterophyllus, known to be rich in flavonoids and phenolic compounds, it undergo ethanolic extraction to isolate its bioactive constituents. The antipyretic effects of the extract was evaluated using a brewer’s yeast-induced pyrexia model in male Swiss mice, with rectal temperature measurements serving as the primary indicator. The study assessed the extract at three concentrations (2000, 3500, 5000 mg/kg), comparing its effectiveness with a negative control (distilled water) and a positive control (paracetamol 10mg/kg) (Öksüz 2020). Acute toxicity tests was also be conducted to establish the safety profile of the extract. Statistical analysis using one-way ANOVAwas performed to determine the significance of the findings. This research aimsto contribute to the growing interest in plant-based medicines and provide insights into the therapeutic activity of A. heterophyllus peel extract for fever management.