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September 10, 2025Cancer Research

Abstract P22: Progestin (R5020) Induced Cell Apoptosis Via Mitochondria-Mediated Cell Death Pathway In MCF-7 Cell With PRB Overexpression

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Authors

QWQian Yee WooPLPheck Khee LauWMWei Meng

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Overview

Research reveals apoptosis in MCF-7 cells treated with progestin, targeting the hypoxia pathway and implicating multiple pro-apoptotic proteins.

Key Points

  • Progestin treatment leads to significant apoptosis in MCF-7 cells with PRB overexpression, highlighting a complex cellular response.
  • Notable changes include upregulation of pro-apoptotic proteins and downregulation of anti-apoptotic proteins in treated cells.
  • Analysis utilized proteomic profiling and Western blotting to explore apoptosis mechanisms induced by R5020 in breast cancer cells.
  • Study findings indicate potential therapeutic implications for targeting hypoxia pathways in breast cancer treatment.

Cite This Study

Woo et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5ff54b1d3bfb60e0253https://doi.org/10.1158/1538-7445.fcs2024-p22
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 3224: Identifying the molecular mechanisms underlying progesterone receptor downregulation in endometrial cancer2024
  2. 2Abstract 5364: Progesterone receptor modulates the antigen processing and presentation machinery decreasing MHC class I expression on tumors2024
  3. 3Abstract A072: BRCA1 depletion enhances progesterone receptor-driven cytoskeletal remodeling in ovarian cancer2025
  4. 4Abstract P36: The Intrinsically Disordered Activation Function 1 of Progesterone Receptor is Required for Regulation of Cell Proliferation2025
  5. 5Abstract 2284: Progesterone receptor modulates the antigen processing and presentation machinery: Decreasing MHC class I expression on tumor2026