Quantitative study shows tumor-stroma interactions shape spheroid self-organization, indicating novel modeling potential.
We present a microfluidic-based 3D model of pancretic cancer that reveals how tumor–stroma interactions and matrix mechanics govern spheroid self-organization. Using quantitative imaging, we uncover cell type–specific growth patterns and stromal responses. This platform advances in vitro modeling of pancretaic cancer heterogeneity and reveals biomechanical drivers of tumor architecture.
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Hatibi et al. (2025) studied this question.
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