Room Temperature Ruthenium-Catalyzed Coupling of Cyclopropanols and α-Diazo-β-ketoesters to α-Ester-δ-diketones

Conventional reactivity chemistry scheme asserts a functional group as the originator of reactivity at the reactive site. We report herein the reactivity transduction chemistry scheme, highlighting reactivity and reactive fragment flow as the drivers for the emergence of reactivity. The reactivity flow of zinc carbenoid and azide differentiates ineffective ketone-β-ketoester cross-coupling reactivity into competent cyclopropyl alcohol-α-diazo carbene cross-coupling reactivity. A room-temperature protocol is developed for ruthenium-catalyzed, broad-substrate-scope coupling of cyclopropyl alcohols and α-diazo-β-ketoesters to α-ester-δ-diketones.