Synthesis and anticancer activity of cyclometalated Pt(ii) neutral complexes containing curcumin as a bioactive ancillary ligand

Eugenia Giorno; Giorgio Facchetti; Nicolas Godbert; Giuseppe Di Maio; Massimo La Deda; Giulia Coffetti; Isabella Rimoldi; Valentina Coccè; Luisa Doneda; Giulio Alessandri; Francesca Paino; Augusto Pessina; Iolinda Aiello

doi:10.1039/d5dt01323b

January 1, 2025Dalton TransactionsOpen Access

Synthesis and anticancer activity of cyclometalated Pt(ii) neutral complexes containing curcumin as a bioactive ancillary ligand

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Key Points

Significant antiproliferative activity was observed without the need for photoactivation, indicating potential therapeutic use.
Curcumin, a natural compound, serves as an ancillary ligand in these cyclometalated platinum(II) complexes.
This synthesis of new Pt(II) complexes may offer a novel approach to anticancer drug development.
The findings underscore the importance of curcumin's role in enhancing the efficacy of platinum-based cancer therapies.

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Implication

Chemical synthesis reveals significant antiproliferative effects of curcumin-platinum(II) compounds, highlighting their potential as cancer treatments.

Abstract

A new series of Pt( ii ) complexes featuring curcumin was synthesized and tested as anticancer drugs. A significant antiproliferative effect is exhibited in the absence of photoactivation.

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Giorno et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e095e https://doi.org/10.1039/d5dt01323b

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Synthesis and anticancer activity of cyclometalated Pt(ii) neutral complexes containing curcumin as a bioactive ancillary ligand

Key Points

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Abstract

Discussion

Cite This Study

Synthesis and anticancer activity of cyclometalated Pt(ii) neutral complexes containing curcumin as a bioactive ancillary ligand

Key Points

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Implication

Abstract

Discussion

Cite This Study

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