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September 10, 2025Cancer Research

Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production

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Observational analysis shows enhanced glycolysis via enolase 1 in tumors, suggesting a new metabolic target.

Exon skipping of Ste20-like kinase enhances glycolysis in tumors, driving progression.
SLKv increases enolase 1 activity, leading to higher phosphoenolpyruvate production.
TGFβ mediates SLK exon skipping by upregulating KHDRBS1 splicing factor.
Targeting SLKv may reduce tumorigenesis by impairing glycolysis.

Chen et al. (2025) studied this question.

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