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Case report demonstrates genetic alterations in CNS involvement of mycosis fungoides, suggesting new insights.
The incidence of central nervous system (CNS) involvement in mycosis fungoides (MF) is low. Here, we report a case of CNS involvement 3 years after MF diagnosis, comparing genetic alterations identified by amplicon-based targeted sequencing between a primary skin sample and a brain tissue sample. TNFAIP3 mutation, MYC gain, CDKN2A/B loss, and SOCS1 loss were concordantly detected, while MYC mutation was only found in the brain sample. This is the first report of a comprehensive genetic analysis of CNS involvement in MF, providing novel insights into genetic factors potentially associated with CNS involvement.
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Nakata et al. (2025) studied this question.
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