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September 10, 2025Nature CommunicationsOpen Access

TLR4+group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases

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Authors

YLYan LiZWZaichuan WangSDSu Duan

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Overview

Observational analysis identifies TLR4+ILC2s enhancing type 2 immunity in chronic rhinosinusitis, implying disease persistence.

Key Points

  • TLR4+ILC2s maintain type 2 immunity in chronic airway diseases, contributing to inflammation and disease chronicity.
  • ILC2s exhibit memory cell markers and respond robustly to secondary antigen challenges in mouse models of airway diseases.
  • Genetic ablation of TLR4 reduces IL-13 expression in ILC2s, indicating its role in regulating mucus production and inflammation.
  • Assessment of chromatin accessibility highlights the significance of TLR4 gene loci in maintaining immune memory in ILC2s.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1aac654b1d3bfb60e33c8https://doi.org/10.1038/s41467-025-62532-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Group 2 innate lymphoid cells: Where are we 15 years out?2026 · 1 citations
  2. 2Heterogeneity and Clinical Relevance of Group 2 Innate Lymphoid Cells Subsets in Nasal Polyps2026 · 2 citations
  3. 3Role of Innate Lymphoid Cells in Chronic Rhinosinusitis: Insights from Tissue and Peripheral Blood Flow Cytometric Analysis2026
  4. 4Role of group 2 innate lymphoid cells in intranasal sensitization-induced allergic rhinitis in mice2025
  5. 5Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps: The Role of Innate Lymphoid Cells and Reprogramming Under IL-4Rα Blockade2026