The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment

Based on current research in neuroscience, systems biology, and clinical medicine, we propose a novel theoretical concept: the “Homeostasis Threshold Deviation (HTD) Theory of Wide-Range Oscillatory Physiological Parameters”. HTD posits that, when the external environment undergoes significant and sustained changes or when visceral signals exhibit long-term abnormalities, central nervous system (CNS) network topologies reset first, establishing a new range of physiological setpoints before peripheral organs adapt. This central reset leads to a deviation in the topological information network structure of central nuclei, resulting in the displacement of the original range of physiological parameters that become challenging to restore. This deviation further triggers passive adaption in peripheral organs, ultimately causing complex multi-organ diseases and severe organ dysfunction. By targeting the CNS threshold shift, HTD provides a novel path for precision medicine. That is, restoring original homeostatic setpoints could enable both early prevention and durable treatment of hypertension and metabolic disorders, achieving a “two birds with one stone” effect or even partially curing related conditions.